The terrorists bulldozing the holly site in the eastern town of Ayn al - Arous in the province of Raqqa early on Thursday.
A radical Wahhabi group affiliated with al - Nusra Front is seen surrounding and then destroying the historic mausoleum.
Earlier this month, the militant groups destroyed the mausoleum of Hujr ibn Adi in the Damascus suburb of Adra and transferred his remains to an unknown location.
The desecration of the revered site belonging to the Shia Muslim figure by the militants in Syria has drawn global condemnations.
Hujr, a close companion of Prophet Mohammad(PBUH) and a loyal supporter of the first Shia Imam Ali ibn Abi Talib(PBUH), led the army of Muslims to victory in several crucial battles.